Management of Chemotherapy-Induced Nausea and Vomiting by Rudolph M. Navari

Author:Rudolph M. Navari
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

While the 5-HT3-mediated phase is short and virtually completed in the first 24 h following chemotherapy administration, the substance P- and NK1-mediated phase in HEC continues for 60–96 h postchemotherapy [25, 26]. The acute phase of chemotherapy has been arbitrary defined as the initial 24 h postchemotherapy and the delayed phase as any time in the 96 h after that. These phase definitions are based on the need for readily measurable endpoints, rather than the biological aspects associated with 5-HT3 and NK1. However, the NK1 RA and 5-HT3 RA are often associated with acute and delayed CINV, respectively. It is apparent that the NK1-mediated effect spans both phases in HEC [25, 27].

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.